Metformin is a frequent prescription for the treatment of type 2 diabetes and is also being used to help patients that are obese and overweight. Metformin has demonstrated its ability to lower complications associated with cardiovascular, LDL (bad cholesterol), triglyceride level and diabetes.
Studies reveal how Metformin lowers hepatic gluconeogenesis but also lowers glucose absorption from the stomach and raises the sensitivity of insulin through an increased peripheral use of glucose.
Characteristics such as safety, ease of use, low cost, tolerability and fewer potential complications are looked for in diabetes medications by physicians. So it is no surprise that Metformin remains the first choice in treatment for type 2 diabetes as it is demonstrates the best risk benefit profile against any other diabetes drug.
In a report in the Journal Annals of Internal Medicine it was discovered by the Johns Hopkins team that metformin was not only able to stabilize blood sugar levels but was also less likely to cause a gain in weight or an increase in cholesterol levels.
According to new John Hopkins research Metformin works just as well as newer and more expensive forms of diabetic medication and has fewer of the side effects associated with half a dozen of the others.
Metformin is able to reduce blood sugar levels through limiting the amount of glucose that is produced in the liver and through making cells more sensitive to insulin.
A study carried out on mice that was published in May 2009 proposed how Metformin performed to reduce blood sugar levels by stimulating a gene that is in the liver directly. This is how glucose production is closed off. Instead of just improving the sensitivity of insulin it is able to bypass the signaling for broken insulin.
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